Five years after the events of Dracula II: Ascension, Father Uffizi and Luke (Jason London) discover that Dracula (Rutger Hauer) has returned with Elizabeth (Diane Neal) to his castle in the Carpathian Mountains. However, fearing that Uffizi has been tainted by Dracula, Cardinal Siqueros (Roy Scheider) refuses to give Uffizi his blessing for the mission. Uffizi defrocks himself and sets out with Luke to Bucharest.
Romania has been devastated by a civil war, and NATO peacekeepers line the streets. In an abandoned village, Uffizi and Luke find a crashed helicopter containing a news reporter, Julia (Alexandra Wescourt), and her cameraman. The cameraman is turned by the vampire clowns terrorising the village, but all are destroyed by Uffizi and Luke. They leave Julia but are soon lured into a rebel trap. They find Julia with the rebels, refusing to return to England with nothing but a story on vampires.
The undead attack the rebel base during the night, but Uffizi, Luke and Julia survive, proceeding to Dracula's castle. There they find Elizabeth, almost totally turned to Dracula's way of life. Dracula mortally wounds Julia and tells Uffizi that only through God's forgiveness can he truly die, but Uffizi engages the ancient vampire in a duel and ultimately destroys him by first biting him and draining him of his blood, then beheading him, announcing that he should consider himself forgiven. Meanwhile, Luke, on her request, beheads Elizabeth. Luke leaves the castle, while Uffizi sits on Dracula's throne, with Julia revived as a vampire. The film ends with the implication that Uffizi, who has missed the morning purge of his vampiric curse, has become the new vampire lord.
- Jason Scott Lee as Father Uffizi
- Rutger Hauer as Dracula/Judas Iscariot
- Diane Neal as Elizabeth Blaine
- Jason London as Luke
- Roy Scheider as Cardinal Siqueros
- Alexandra Wescourt as Julia Hughes
- Claudiu Bleonț as Bogdan
- Serban Celea as Gabriel
- Ioana Ginghina as Bride of Dracula
- Ilinca Goia as Marta
- George Grigore as Bruno
- Ioan Ionescu as Ragman
- Tom Kane as EBC Anchorma